oestrogen receptor

oestrogen receptor
a specific site on the surface of a cell that binds to oestrogen; the binding triggers responses of the cell to the hormone (see receptor). Oestrogen receptors occur on all target cells normally responsive to oestrogen (e.g. in the uterus) and are also found on some cancer cells, particularly in breast cancer. Oestrogen-receptor-positive cancer cells rely on oestrogen to grow and are therefore susceptible to anti-oestrogen therapy, which prevents oestrogen from binding to these receptors. This type of cancer tends to have a better prognosis than oestrogen-receptor-negative breast cancer.

The new mediacal dictionary. 2014.

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  • oestrogen receptor — a specific site on the surface of a cell that binds to oestrogen; the binding triggers responses of the cell to the hormone. anti oestrogen, used for treating breast cancer, act by preventing the binding of oestrogen to these receptor …   Medical dictionary

  • oestrogen-receptor antagonist — see anti oestrogen …   The new mediacal dictionary

  • Receptor — In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are hoards of receptors. There are receptors for insulin, receptors for low density lipoproteins (LDL), etc.… …   Medical dictionary

  • anti-oestrogen — oestrogen receptor antagonist; n. one of a group of drugs that oppose the action of oestrogen by binding to oestrogen receptors in the body s tissues. The most important of these drugs is currently tamoxifen, which is used in the treatment of… …   The new mediacal dictionary

  • receptor — n. 1) a cell or group of cells specialized to detect changes in the environment and trigger impulses in the sensory nervous system. All sensory nerve endings act as receptors, whether they simply detect touch, as in the skin, or chemical… …   The new mediacal dictionary

  • Estrogen receptor alpha — Estrogen receptor 1 PDB rendering based on 1a52 …   Wikipedia

  • Estrogen receptor beta — See also: Estrogen receptor Estrogen receptor 2 (ER beta) PDB rendering based on 1hj1 …   Wikipedia

  • Nuclear receptor — Crystallographic structure of a heterodimer of the nuclear receptors PPAR γ (green) and RXR α (cyan) bound to double stranded DNA (magenta) and two molecules of the NCOA2 coactivator (red). The PPAR γ antagonist GW9662 and RXR α agonist retinoic… …   Wikipedia

  • Nuclear receptor coactivator 3 — NCOA3 activation domain 1 (AD1) bound to a portion of CBP. PDB rendering based on 1kbh …   Wikipedia

  • Nuclear receptor coactivator 1 — PDB rendering based on 1oj5 …   Wikipedia

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